Basically creatinine is a metabolite originated from creatine, this is a kind of paste that serves as a source of energy for muscles. This molecule is constantly produced in the body, but its production varies depending on the muscle mass from one person to another. Men tend to produce higher levels of creatinine than women because they possess greater muscle mass. Because creatinine is almost exclusively eliminated through the kidneys, the amount of creatinine in the blood or serum creatinine is often indicative of how renal filtration is working.
Creatinine levels increase in the blood to pathological values when the kidneys are not adequately filtering, that is, with the advanced loss of renal function. However, creatinine levels can be determined through a standard blood test, which is relatively simple and fast. This test is usually the first step in determining the glomerular filtration rate (GFR), which is used by specialists to diagnose kidney disease. According to the levels obtained in the analyzes of GFR, doctors can classify diseases according to the different levels of severity. Medications like gentamicin can cause damage directly to the kidney. When there is a treatment that leads to a possible kidney injury, specialists usually have their patients perform creatinine levels tests to see if the kidneys are functioning normally, and in case of anomalies, they act quickly.
As a person ages the creatinine concentration tends to increase, because the function of the filtrate of the kidneys deteriorates with age. For this reason, slightly higher normal values of creatinine are applied for people over 50 years of age. Normal creatinine values range from 0.7 to 1.3 mg / dL for men and from 0.6 to 1.1 mg / dL for women. Women usually have lower levels of creatinine than men, since they have less muscle mass.
Factors that increase creatinine:
There are a variety of factors or causes that can influence the elevation or decrease of creatinine levels in the body. The most common causes of increased creatinine levels are:
Renal failure, acute or chronic.
Rabdomiliosis, consists of a mechanism in which the muscles are decomposing.
Calculations in the bladder, malformations or professional hydroferosis, any other urinary tract disorder.
Some drugs such as aminoglycosides, erythromycin, etc.
Therapies with cytotoxic drugs or antibiotics. Excessive consumption of meat.
The presence of very enlarged limbs of the body such as the toes or hands, hands, nose, chin, among others. This anomaly is known as acromegaly.
Factors that lower creatinine:
The most common factors that cause creatinine levels to decrease are:
Beginning of diabetes mellitus.
Decreased muscle mass.